This book elucidates the diagnostic criteria and concept of asthma-COPD overlap (ACO) and provides the latest information on its epidemiology, pathophysiology, diagnostic criteria, and treatment options. It discusses the controversy-causing findings of prognosis of ACO, the novel molecular mechanism including nitrosative stress, radiological or physiological features, findings by research that used HRCT or forced oscillation technique. In addition to a recent animal model of ACO, the role of each biomarker, the latest results of ICS/LAMA/LABA combination inhalers or biologics is also debated.
Asthma COPD Overlap -Updated Concept, Pathophysiology, Diagnosis, and Treatment is addressed not only to beginners, but also to physicians engaged in clinical practice, supervisors, and many basic researchers. Covering every aspect of ACO, it serves readers to improve diagnosis or treatment for patients with ACO.
Table of contents (18 chapters)
Front Matter
Pages i-viii
Concept of Asthma COPD Overlap
Front Matter
Pages 1-1
Concept of Asthma COPD Overlap: Japanese Guideline and Global Trends—How Was the Concept of Asthma COPD Overlap Developed and Moving Forward?
Mitsuhiro Yamada, Masakazu Ichinose
Pages 3-16
Concept of Treatable Traits and ACO: Can Treatable Traits Approach Be Applied into Practice?
Hironori Masuko, Nobuyuki Hizawa
Pages 17-26
Epidemiology and Prognosis
Front Matter
Pages 27-27
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Epidemiology of ACO from Global Data: Does the Prevalence of ACO Vary Among Global Analyses?
Kentaro Machida, Takahiro Matsuyama, Hiromi Matsuyama, Koichi Takagi, Hiromasa Inoue
Pages 29-45
Epidemiology of ACO Defined by the JRS Guidelines: What Is the Prevalence of ACO in Japan?
Kuniaki Hirai, Hiroyuki Nagase
Pages 47-55
Prognosis and Characteristics of ACO: What Are the Specific Characteristics of ACO?
Seiichi Kobayashi
Pages 57-68
Prognosis of COPD with Asthma-Like Features and ACO: Is the Prognosis of COPD and ACO Different?
Masaru Suzuki
Pages 69-78
Causes of Death in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap: Is There Any Difference Compared to Asthma?
Akira Yamasaki, Tomoya Harada, Katsuyuki Tomita
Pages 79-95
Pathophysiology of ACO
Front Matter
Pages 97-97
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Inflammatory Phenotypes and Potential Bio-markers of ACO: What Is the Specific Feature of ACO?
Keita Hirai
Pages 99-110
Role of Nitrosative Stress: What Is the Potential Clinical Implication?
Tomohiro Ichikawa, Hisatoshi Sugiura
Pages 111-125
Radiographic Features of ACO: How Is the Feature Applied to Practice?
Masato Karayama, Naoki Inui
Pages 127-143
Pulmonary Function of ACO: What Is the Role of the Forced Oscillation Technique?
Toshihiro Shirai
Pages 145-157
Underlying Mechanism Suggested by the ACO Model: What Is the Lesson Learned from the Model?
Hirotaka Matsuzaki, Kensuke Fukuda, Yoshihisa Hiraishi
Pages 159-170
Diagnosis of ACO
Front Matter
Pages 171-171
Comparison of Diagnostic Criteria of ACO: What Is the Point of Difference?
Akira Koarai
Pages 173-185
Role of FeNO: How Can FeNO Be Positioned in Practice?
Naoya Fujino
Pages 187-201
Role of IgE and Eosinophils: The Use of Type 2 Biomarkers in Practice
Hiroyuki Nagase, Hikaru Toyota
Pages 203-218
Diagnosis of ACO
Rhinosinusitis in ACO: What Is the Implication of Nasal Comorbidity?
Satoshi Hamada
Pages 219-229
Treatment
Front Matter
Pages 231-231
Current Evidence of Treatment for Asthma-COPD Overlap (ACO): Is There Emerging Evidence of Optimal Therapy?—In Asthma COPD Overlap: Updated Concept, Pathophysiology, Diagnosis and Treatment
Yoshihisa Ishiura, Shosaku Nomura, Takeshi Tamaki, Toshiki Shimizu, Naoyuki Miyashita, Tomoki Ito
Pages 233-240
Potential Treatment Options for ACO, Including Biologics: Are There Any Roles of Biologics?
Nobuhisa Ishikawa
Pages 241-258
