The risk of clinically significant drug interaction rises when a patient increases his intake of medication. While drug interaction can be a prominent cause of illness, in many cases, it can be avoided with proper knowledge and care. This text provides a concise yet comprehensive review of common drug interactions in gastroenterology.
The book begins with a preliminary overview of GI drugs, focusing on legal aspects of drug use, clinical research and regulatory review, and drug development. The next section goes over the basic pharmacology of GI drugs, specifically profiling antisecretory drugs, motility drugs, mucosal protective agents, antibiotics, and anti-inflammatory drugs. The third section of the text reviews important aspects of drug interaction; topics covered in this section include the different types of drug interactions, adverse drug reactions and interactions, enzymes and transporters involved in drug interactions, pharmacogenomics, drug-herbal interactions, drug-food interactions, and ways to avoid drug interactions altogether.
The book moves on to examine comorbidity and digestive diseases that can result from drug interactions, with particular emphasis on infections, cardiorespiratory disorders, renal insufficiency, IBS, metabolic disorders, and CNS disorders. This section also discusses the influence of age on drug interactions. The final section spotlights comedication that can be used to mitigate disorders caused by drug interactions, specifically reviewing comedication used to treat acid-related disorders, intestinal inflammation, liver disorders, pancreato-biliary disorders, and motility disorders. The text also includes over 100 high-yield illustrations, photographs, and tables.
Table of contents (32 chapters)
Front Matter
Pages i-xxi
Drug Journey: From Substance to Drug
Front Matter
Pages 1-1
Regulatory and Legal Aspects of the Drug Lifecycle
Velimir Šimičević
Pages 3-12
Preclinical Research in Drug Discovery
Roberto Antolović, Dubravko Jelić, Darko Marković
Pages 13-28
Clinical Research and Regulatory Review
Matea Radačić Aumiler, Ines Baotić
Pages 29-39
DDI and Drug Development
Damir Erceg, Aurora Antolović Amidžić
Pages 41-55
Basic Pharmacology of GI Drugs
Front Matter
Pages 57-57
Antisecretory Drugs
Robert Smolić, Sonja Vukadin, Lucija Kuna
Pages 59-67
Motility Drugs
Rosana Troskot Perić, Nikolina Tolj, Marina Madunić, Ana Maria Soldo
Pages 69-82
Mucosal Protective Agents
Aleksandar Včev, Tea Omanović Kolarić, Hrvoje Roguljić
Pages 83-91
Antimicrobial Drugs
Sanja Pleško, Gabrijela Perše, Zrinka Todorić, Ivana Mareković
Pages 93-133
Anti-inflammatory Drugs and the Gastrointestinal Tract
Mladen Merćep
Pages 135-162
Basics of Drug Interactions
Front Matter
Pages 163-163
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Adverse Drug Reactions and Drug Interactions
Damir Erceg, Nikola Raguž-Lučić, Sabina Steiner Srdarević
Pages 165-176
Types of Drug Interactions
Martina Smolić, Kristina Bojanić, Kristina Duspara, Sonja Vukadin
Pages 177-190
Enzymes and Transporters Involved in Drug Interactions
Ines Bilić Ćurčić, Vjera Ninčević, Tomislav Kizivat, Nikola Raguž-Lučić
Pages 191-202
Pharmacogenomics of Drugs Used in Gastroenterology
Lidija Bach-Rojecky, Dragan Primorac
Pages 203-213
Interactions of Drugs and Herbs in Gastroenterology
Agostino Di Ciaula, David Q.-H. Wang, Piero Portincasa
Pages 215-243
Food-Drug Interactions
Eva Pavić, Valentina Rahelić
Pages 245-263
How to Avoid Drug Interactions
Vesna Bačić Vrca, Ivana Samardžić
Pages 265-277
Comorbidity in Digestive Diseases
Front Matter
Pages 279-279
Influence of Disease on Drug Interaction
Marko Luka Bošković, Robert Likić
Pages 281-289
Functional Status of GI Mucosa and Oral Drug Absorption
Srećko Marušić, Ivana Marinović, Ivana Samardžić
Pages 291-308
Infections
Rok Čivljak, Marta Perović Mihanović
Pages 309-328
Cardiorespiratory Disorders
Mario Udovičić, Danijela Grizelj, Hrvoje Falak
Pages 329-345
Renal Insufficiency
Ivica Horvatić, Ivan Durlen
Pages 347-365
Hepatic Insufficiency
Ivana Mikolašević, Tajana Filipec Kanižaj, Viktor Domislović, Duško Kardum
Pages 367-382
Comorbidity and Comedication in Irritable Bowel Syndrome Patients
Žarko Babić
Pages 383-402
Metabolic Disorders
Dario Rahelić, Lucija Romić, Marija Martinović, Sanja Klobučar
Pages 403-418
Immune-Mediated Disorders
Mirjana Turkalj
Pages 419-431
Nervous System Disorders
Silvio Bašić, Romana Gjergja Juraški, Ivana Marković
Pages 433-474
Comedication and Drug Interactions in Gastroenterology
Front Matter
Pages 475-475
Acid-Related Disorders
Marinko Marušić, Mia Knobloch, Matej Paić
Pages 477-508
Intestinal Inflammation: Conventional Anti-Inflammatory Drugs
Alen Bišćanin, Petra Ćaćić, Marko Banić
Pages 509-551
Intestinal Inflammation: Biologics and Small Molecules
Marko Banić, Željko Krznarić, Marko Brinar, Marija Urek, Milenko Bevanda
Pages 553-574
Interactions of Drugs for Liver Diseases
Marina Mudrovčić, Lucija Virović Jukić, Doris Ogresta, Ivica Grgurević
Pages 575-639
Pancreato-Biliary Disorders
Tomislav Bokun, Marko Zelenika, Milan Kujundžić
Pages 641-653
Comedication and Drug Interactions in Functional Gastrointestinal Disorders
Andreea Farcas, Camelia Bucsa, Dan Dumitrascu
Pages 655-671
Back Matter
Pages 673-686
