Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift

This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, expertly contextualizes dementia research within the respective zeitgeist and summarizes the critical paths that have led to the currently available Alzheimer’s drugs.

As readers journey through the major developments in Alzheimer’s Disease research, particularly over the past thirty years, Behl poses thought-provoking questions: Why are the exact causes of Alzheimer’s Disease still shrouded in mystery, despite immense global research efforts in both academia and the pharmaceutical industry? Why has a significant portion of the research community remained focused on a single hypothesis—the deposition of the amyloid beta peptide in the brain—as the primary trigger for Alzheimer’s pathology, even though this concept has yet to be convincingly validated in clinical settings? Are there alternative hypotheses that might better explain the pathogenesis of this complex brain disease, and if so, why haven’t these perspectives been adequately explored?

In this enlightening book, Behl endeavors to answer these pivotal questions. Beginning with a comprehensive historical background, the author illustrates the long and challenging research journey, including numerous setbacks and the growing acceptance of alternative explanations for the disease within the Alzheimer’s research community.

With a deep dive into the history and progression of this critical research area, including the most recent advancements, Behl argues that it is high time to promote a much-needed paradigm shift in Alzheimer’s Disease research.

This book is tailored for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who seek an in-depth understanding of the key developments in one of the most prominent research fields of our time. With extensive literature

Authors:

Christian Behl (Author)

Edition:

2023rd

Publication Date:

July 14, 2023

From the book: