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Front Matter (Pages: i-xlvi)
CHAPTER 1
Inflammation through the Ages: A Historical Perspective (Pages: 1-16)
Jean-Marc Cavaillon
Part One : Inducers and Sensors of Inflammation
CHAPTER 2
Pathogen-associated Molecular Patterns (Pages: 17-56)
Jean-Marc Cavaillon
CHAPTER 3
Damage-associated Molecular Patterns (Pages: 57-80)
Jean-Marc Cavaillon
CHAPTER 4
Bacterial Toxins (Pages: 81-98)
Marina de Bernard, Cesare Montecucco
CHAPTER 5
Venoms (Pages: 99-128)
Catarina Teixeira, Vanessa Moreira, José María Gutiérrez
CHAPTER 6
Hypoxia as an Inducer of Inflammation (Pages: 129-142)
Ariel Brandwein, Clifford S. Deutschman
References
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CHAPTER 7
Vaccine Adjuvants (Pages: 143-174)
Dennis M. Klinman, Hidekazu Shirota
CHAPTER 8
Pattern Recognition Receptors (Pages: 175-216)
Lauren Whitehead, Gordon D. Brown
Part Two : Inflammatory Cells
CHAPTER 9
Monocytes and Macrophages (Pages: 217-252)
Irina N. Shalova, Shilpi Saha, Subhra K. Biswas
CHAPTER 10
Neutrophils (Pages: 253-272)
Salvatore Cuzzocrea
CHAPTER 11
Mast Cells: Master Drivers of Immune Responses against Pathogens (Pages: 273-288)
W.X. Gladys Ang, Soman N. Abraham
CHAPTER 12
Dendritic Cells in Inflammatory Disease (Pages: 289-314)
Bart N. Lambrecht, Martin Guilliams, Hamida Hammad
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CHAPTER 13
Roles for NK Cells and ILC1 in Inflammation and Infection (Pages: 315-340)
Christian A.J. Vosshenrich, James P. Di Santo
CHAPTER 14
Group 2 and 3 Innate Lymphoid Cells: New Actors in Immunity and Inflammation (Pages: 341-364)
Nicolas Serafini, James P. Di Santo
CHAPTER 15
Th9 Cells: From the Bench to the Bedside and Back Again (Pages: 365-394)
Benjamin J. Ulrich, Matthew M. Hufford, Mark H. Kaplan
CHAPTER 16
Th17 Cells (Pages: 395-418)
Mélissa Noack, Pierre Miossec
CHAPTER 17
Platelets (Pages: 419-436)
Jack Levin
CHAPTER 18
Epithelial Cells (Pages: 437-456)
Jill M. Hoffman, Charalabos Pothoulakis
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CHAPTER 19
Inflammation: The Role of Endothelial Cells (Pages: 457-476)
J. Steven Alexander, D. Neil Granger, Norman R. Harris
Part Three : Inflammatory Mediators
CHAPTER 20
IL-1 Superfamily and Inflammasome (Pages: 477-528)
Charles A. Dinarello
CHAPTER 21
TNF Superfamily (Pages: 529-547)
Salvatore Cuzzocrea
CHAPTER 22
Interleukin-17 A-E (Pages: 549-572)
Giovanni Monteleone, Irene Marafini, Edoardo Troncone
CHAPTER 23
IL-6 Superfamily (Pages: 573-586)
Toshio Tanaka, Masashi Narazaki, Tadamistu Kishimoto
CHAPTER 24
Type I and II Cytokine Superfamilies in Inflammatory Responses (Pages: 587-618)
William F. Carson IV, Steven L. Kunkel
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CHAPTER 25
Chemokines and Chemotaxis (Pages: 619-650)
Osamu Yoshie, Kouji Matsushima
CHAPTER 26
Lipid Mediators in Inflammation (Pages: 651-694)
Shuh Narumiya, Takehiko Yokomizo, Junken Aoki
CHAPTER 27
Free Radicals in Inflammation (Pages: 695-726)
Andrew Cumpstey, Martin Feelisch
CHAPTER 28
Proteases (Pages: 727-766)
Celine Deraison, Chrystelle Bonnart, Nathalie Vergnolle
CHAPTER 29
Psychiatric Disorders and Inflammation (Pages: 767-784)
Robert Dantzer
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CHAPTER 30
Complement System (Pages: 785-812)
Peter A. Ward, Claudia Kemper
CHAPTER 31
Heat Shock Proteins (Pages: 813-830)
Willem van Eden, Femke Broere, Ruurd van der Zee
Part Four : Inflammation and Host Response
CHAPTER 32
Inflammation and Coagulation (Pages: 833-860)
Marcel Levi
CHAPTER 33
Fever: Mediators and Mechanisms (Pages: 861-890)
Joachim Roth
CHAPTER 34
Pain (Pages: 891-914)
Christoph Stein
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CHAPTER 35
Inflammation, Hormones, and Metabolism (Pages: 915-946)
Muska Khpal, Mervyn Singer
CHAPTER 36
Microenvironmental Regulation of Innate Immune Cell Function (Pages: 947-970)
Emily R. Watts, Eilise Ryan, Sarah R. Walmsley, Moira K.B. Whyte
CHAPTER 37
Epigenetics of Inflammation (Pages: 971-992)
Vidula Vachharajani, Charles E. McCall
Part Five : Inflammation and Diseases
CHAPTER 38
Allergy and Inflammation (Pages: 995-1030)
Milena Sokołowska, Anna Głobińska, Cezmi A. Akdis
CHAPTER 39
Sepsis (Pages: 1031-1052)
Manu Shankar-Hari, Mervyn Singer
CHAPTER 40
Autoimmunity and Inflammation (Pages: 1053-1090)
Shrikant Ramesh Mulay, Onkar P. Kulkarni, Khader Rupanagudi, Hans-Joachim Anders
References
CHAPTER 41
Psoriasis and Other Skin Inflammatory Diseases (Pages: 1091-1104)
Jaehwan Kim, James G. Krueger
CHAPTER 42
Rheumatoid Arthritis and Other Inflammatory Articular Diseases (Pages: 1105-1140)
Rogier M. Thurlings, Sander W. Tas, Paul Peter Tak*
CHAPTER 43
Missing Heritability of Crohn’s Disease and Implications for Therapeutic Targeting and Improved Care (Pages: 1141-1146)
Matthias Chamaillard
CHAPTER 44
Inflammation and Transplantation (Pages: 1147-1172)
William M. Baldwin, III, Robert L. Fairchild
References
CHAPTER 45
Inflammatory Mechanisms in Chronic Obstructive Pulmonary Disease (Pages: 1173-1198)
Peter J. Barnes
CHAPTER 46
Obesity: A Complex Disease with Immune Components (Pages: 1199-1224)
Yuejun Liu, Karine Clément
CHAPTER 47
Inflammation and Type 2 Diabetes (Pages: 1225-1254)
Marleen M.J. van Greevenbroek, Casper G. Schalkwijk, Coen D.A. Stehouwer
CHAPTER 48
Inflammation-Mediated Neurodegeneration: Models, Mechanisms, and Therapeutic Interventions for Neurodegenerative Diseases (Pages: 1255-1278)
Hui-Ming Gao, Yun Gao, Dezhen Tu, Yue Liu, Hui Zhou, Jau-Shyong Hong
CHAPTER 49
Inflammation in Atherosclerosis (Pages: 1279-1300)
Mario A.R. Lauterbach, Larisa I. Labzin, Eicke Latz
CHAPTER 50
Acute Kidney Injury (Pages: 1301-1312)
Johan Mårtensson, Rinaldo Bellomo
References
CHAPTER 51
Ischemia–Reperfusion Syndrome (Pages: 1313-1328)
Christophe Adrie, Sally A. Shin, Mehran Monchi
CHAPTER 52
Single-Nucleotide Polymorphisms and Inflammation (Pages: 1329-1346)
Evangelos J. Giamarellos-Bourboulis
Part Six : Resolution of Inflammation and Tissue Repair
CHAPTER 53
Pentraxins in the Orchestration of Defense and Tissue Repair during the Acute Phase Response (Pages: 1347-1362)
Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi
CHAPTER 54
Anti-Inflammatory Cytokines, Soluble Receptors, and Natural Antagonists (Pages: 1363-1376)
Willem Joost Wiersinga, Tom van der Poll
CHAPTER 55
Regulatory T Cells (Pages: 1377-1422)
Luciana Berod, Katharina Lahl, Matthias Lochner, Christian T. Mayer, Tim Sparwasser
CHAPTER 56
Leukocyte Reprogramming (Pages: 1423-1446)
Jean-Marc Cavaillon
CHAPTER 57
Roles of Specialized Proresolving Lipid Mediators in Inflammation Resolution and Tissue Repair (Pages: 1447-1466)
Matthew Spite, Charles N. Serhan
CHAPTER 58
Glucocorticoids (Pages: 1467-1484)
Heming Nicholas, Annane Djillali
CHAPTER 59
The Neuroimmune Communicatome in Inflammation (Pages: 1485-1516)
Peder S. Olofsson, Christine N. Metz, Valentin A. Pavlov
Summary
The Inflammatory Response in Tissue Repair (Pages: 1517-1538)
Nikolaos G. Frangogiannis
Part Seven : Detection and Treatments
CHAPTER 61
Biomarkers in Inflammation (Pages: 1539-1566)
Andreas Kortgen, Michael Bauer
CHAPTER 62
In Vivo Imaging of Inflammation (Pages: 1567-1582)
Anne Roivainen, Antti Saraste
Summary
CHAPTER 63
Novel Targets for Drug Development (Pages: 1583-1608)
Alan S. Cross, Steven M. Opal
CHAPTER 64
Inflammation and Microbiota and Gut Reconditioning (Pages: 1609-1660)
Stig Bengmark
CHAPTER 65
Natural Products as Source of Anti-Inflammatory Drugs (Pages: 1661-1690)
Shivaprasad H. Venkatesha, Bodhraj Acharya, Kamal D. Moudgil
About the Author
Jean-Marc Cavaillon is professor and Head of the Unit “Cytokines and Inflammation” at Institut Pasteur (Paris). He has been President of the “International Endotoxin and Innate Immunity Society”. He is member of the Editorial Boards of few journals including Shock, Journal of Infectious Diseases, and International Journal of Inflammation, and has been Associate-Editor of “Cytokine” (2002-2009).
Jean-Marc Cavaillon has an extensive expertise in innate immunity, particularly on cytokines, inflammation, bacterial endotoxins and other Toll-like receptors agonists, endotoxin tolerance, activation of monocytes/macrophages and neutrophils, altered immune status in sepsis and SIRS patients. He is the co-author of a book “Sepsis and non-infectious inflammation: from biology to critical care” (Wiley VCH, 2009) and the author of a book in French on cytokines (Masson, 1993 & 1996) . Jean-Marc Cavaillon has published 145 scientific articles, 77 reviews and 45 chapters in books.
Mervyn Singer is Professor of Intensive Care Medicine at University College London. His primary research interests are sepsis and multi-organ failure, infection, shock and haemodynamic monitoring. Funding for these activities primarily comes from the Wellcome Trust, Medical Research Council and National Institute for Health Research. He developed an oesophageal Doppler haemodynamic monitor that is now in widespread use worldwide, the use of which has been shown in multiple studies to improve outcomes after major surgery and reduce length of stay. He has led on a number of important multi-centre trials in critical care. He has authored various papers and textbooks including the Oxford Handbook of Critical Care, now in its 3rd Edition, and is a Council member of the International Sepsis Forum. He was the first UK intensivist to be awarded Senior Investigator status by the National Institute for Health Research, and to be invited to give plenary lectures at the European and US Intensive Care Congresses.
