This volume is designed to impart the fundamental concepts in experimental pharmacology, research methodology and biostatistics. Through this book, the readers will learn about different methods involved in drug discovery, experimental animals and their care, equipments and the various bioassays used in experimental pharmacology. This book contains special sections on various drug screening methods involved in the evaluation of different body systems. Certain sections provide the healthcare professionals with the knowledge necessary to interpret clinical research articles, design clinical studies, and learn essential concepts in biostatistics in an expedient and concise manner. Basic principles and applications of simple analytical methods employed in drug analysis are well written under one section.
It focuses on the basic and advanced laboratory techniques and also on computer simulated data, written extensively under the Biostatistics section. The methods used for drug analysis have been described in adequate detail with cross-references for further studies and comprehension. Overall, the book is designed systematically with four broad sections with extensive subdivisions for easy tracking, interpretation, and understanding.
Table of contents (64 chapters)
Front Matter
Pages i-xxix
Experimental Pharmacology
Front Matter
Pages 1-1
Experimental Methodologies Involved in the Discovery of Drugs
Abialbon Paul
Pages 3-12
Laboratory Animals
Mageshwaran Lakshmanan
Pages 13-36
Care and Handling of Laboratory Animals
Subramani Parasuraman
Pages 37-43
Biological Sample Collection from Experimental Animals
Subramani Parasuraman, Ramasamy Raveendran
Pages 45-63
Anesthesia and Euthanasia of Experimental Animals
Subramani Parasuraman, Parayil Varghese Christapher
Pages 65-75
Equipments in Experimental Pharmacology
R. Kirubakaran
Pages 77-100
Bioassay and Experiments on Isolated Muscle Preparations
Mageshwaran Lakshmanan
Pages 101-113
Experiments on Anaesthetized Intact Animals
Amruta Tripathy
Pages 115-125
Bioassay of Standard Compounds
B. P. V. Sunanda, Rammohan Bondha
Pages 127-142
Principles of EC50, ED50, pD2 and pA2 Values of Drugs
Avinash Arivazhahan
Pages 143-149
Physiological Salt Solutions
Saranya Vilvanathan
Pages 151-156
Validation of Animal Models
Umamaheswari Subramanian
Pages 157-170
Screening Methods for the Evaluation of Antidepressant Drugs
Alphienes Stanley Xavier
Pages 171-181
Screening Methods for the Evaluation of Antiepileptic Drugs
Jayapriya Balamurugam, Mageshwaran Lakshmanan
Pages 183-204
Screening Methods for the Evaluation of General Anaesthetics
Kiruthika Sivagourounadin
Pages 205-212
Screening Methods for the Evaluation of Antipsychotic Drugs
Manu Jose, Mageshwaran Lakshmanan
Pages 213-230
Screening Methods for the Evaluation of Sedative-Hypnotics
Manu Jose, Mageshwaran Lakshmanan
Pages 231-240
Screening Methods for the Evaluation of Anxiolytic Drugs
Gandham Ravi, Madhavi Eerike
Pages 241-249
Experimental Pharmacology
Screening Methods for the Evaluation of Antiparkinsonian Drugs
Mageshwaran Lakshmanan
Pages 251-264
Screening Methods for the Evaluation of Drugs for Learning and Memory
Manu Jose, Mageshwaran Lakshmanan
Pages 265-282
Screening Methods for the Evaluation of Antianginal Agents
Saranya Vilvanathan
Pages 283-296
Screening Methods for the Evaluation of Antihypertensive Drugs
Saranya Vilvanathan
Pages 297-309
Screening Methods for the Evaluation of Antiarrhythmic Drugs
Saranya Vilvanathan
Pages 311-321
Screening Methods for the Evaluation of Cardiotonic Drugs
Abialbon Paul
Pages 323-331
Screening Methods for the Evaluation of Antiplatelet Drugs
Ilanthamizhan Jayakumar
Pages 333-344
Screening Methods for the Evaluation of Diuretics
Nishanthi Anandabaskar
Pages 345-362
Screening Methods for the Evaluation of Antihyperlipidemic Drugs
Bertilla Benjamin
Pages 363-369
Screening Methods for the Evaluation of Antiulcer Drugs
B. Maharani
Pages 371-382
Screening Methods for the Evaluation of Antidiarrheal Drugs
B. Maharani
Pages 383-389
Screening Methods for the Evaluation of Antiemetics
B. Maharani
Pages 391-400
Screening Methods for the Evaluation of Hepatoprotective Agents
Jayapriya Balamurugan, Lourdu Jafrin
Pages 401-412
Screening Methods for the Evaluation of Antiobesity Drugs
Lourdu Jafrin, Mageshwaran Lakshmanan
Pages 413-427
Absorption Studies
Muthu Meera Ramasubramanian
Pages 429-436
Screening Methods for the Evaluation of Antiasthmatic Agents
Neel Jayesh Shah
Pages 437-441
Screening Methods for the Evaluation of Antitussives and Expectorants
Lakshmi Balasundaram
Pages 443-451
Screening Methods for the Evaluation of Antidiabetic Drugs
Avinash Arivazhahan
Pages 453-463
Screening Methods for the Evaluation of Antithyroid Drugs
Suja Xaviar
Pages 465-472
Screening Methods for the Evaluation of Antifertility Drugs
Selvalaxmi Gnanasegaran, Mangaiarkkarasi Adhimoolam
Pages 473-492
Experimental Pharmacology
Screening Methods for the Evaluation of the Drugs Acting on Posterior Pituitary, Adrenal Steroid, Testicular, Parathyroid, Ovarian, and Thyroid Hormones
Sushil Kiran Kunder
Pages 493-501
Screening Methods for the Evaluation of Analgesics, Anti-Inflammatory Drugs, and Antipyretics
Avinash Arivazhahan
Pages 503-522
Screening Methods for the Evaluation of Antiglaucoma and Anticataract Drugs
Rupadevi Muthaiah
Pages 523-539
Screening Methods for the Evaluation of Drugs Affecting Peripheral Nerve Functions
Avinash Arivazhahan
Pages 541-547
Mutagenic Toxicity Testing
Kiruthika Sivagourounadin
Pages 549-571
Screening Methods for the Evaluation of Anticancer Drugs
A. Vimala Ananthy
Pages 573-583
Screening Methods for the Evaluation of Drugs for Benign Prostatic Hyperplasia
S. C. Santosh Kumar
Pages 585-601
Screening Methods for the Evaluation of Drugs Acting on Autonomic Nervous System
Dhivya Elango
Pages 603-611
Screening Methods for the Evaluation of Anti-Infective Agents
Sushil Kiran Kunder, Avinash Arivazhahan
Pages 613-623
Preclinical Toxicity Studies
Mageshwaran Lakshmanan
Pages 625-648
Ethical Issues in Animal Research
Gerard Marshall Raj, Rekha Priyadarshini
Pages 649-684
Good Laboratory Practice (GLP)
Alphienes Stanley Xavier
Pages 685-693
Biochemical Pharmacology
Front Matter
Pages 695-695
Download chapter PDF
Basic Principles and Applications of Simple Analytical Methods
Abialbon Paul
Pages 697-703
Principles of Quantitative Estimation of Drugs, Endogenous Compounds, and Poisons—1
Aarthi Manoharan
Pages 705-722
Principles of Quantitative Estimation of Drugs, Endogenous Compounds, and Poisons—2
Charukesi Rajulu, Arun Kumar Tharkeshwar, Sivaranjani Arumugam, R. Padmapriya
Pages 723-771
Plant Extraction Methods
Mageshwaran Lakshmanan
Pages 773-783
Research Methodology
Front Matter
Pages 785-785
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Literature Search
Mourouguessine Vimal
Pages 787-798
Study Designs
Avinash Arivazhahan, Jhananey Senthilvelan
Pages 799-817
Research Methodology
Ethical Issues Related to Medical Research on Human Participants
Gerard Marshall Raj
Pages 819-837
Biostatistics
Front Matter
Pages 839-839
Download chapter PDF
Basic Principles and Application of Statistics in Drug Research
Abialbon Paul
Pages 841-846
Calculation of Basic Statistical Parameters
Gomathi Ramaswamy
Pages 847-864
Hypothesis Testing
Lakshmi Balasundaram
Pages 865-875
Parametric Tests
Mourouguessine Vimal, Vinayagamoorthy Venugopal, Nishanthi Anandabaskar
Pages 877-888
Non-parametric Tests
Amod Tilak, Avinash Arivazhahan
Pages 889-896
Common Errors in Using Statistical Tools and Data Presentation
Mageshwaran Lakshmanan
Pages 897-910
Correction to: Hypothesis Testing
Lakshmi Balasundaram
Pages C1-C2
